허피스바이러스 유전자 발현, DNA 복제, 비리온 성숙
HCMV에 의한 내인성 및 선천 면역 반응 조절
허피스바이러스와 유비퀴틴 및 유비퀴틴 유사 단백질-변형 시스템의 상호작용
바이러스 유전체에서 구아닌 사중구조의 기능
학력
(Ph.D.) 서울대학교 자연과학대학 미생물학과 (1994)
(M.S.) 서울대학교 자연과학대학 미생물학과 (1988)
(B.S.) 서울대학교 자연과학대학 미생물학과 (1986)
약력/경력
성균관대학교 의과대학 미샐물학교실 조교수/부교수/교수 (2001-)
Johns Hopkins 의과대학, Dept. of Oncology, Research Associate (2000)
Johns Hopkins 의과대학, Dept. of Pharmacology and Molecular Sciences, Post-doc. Fellow (1994-1999)
학술지 논문
(2024)
Varicella zoster virus glycoprotein E facilitates PINK1/Parkin-mediated mitophagy to evade STING and MAVS-mediated antiviral innate immunity.
CELL DEATH & DISEASE.
15,
1
(2023)
Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome inhibits viral infection via translational suppression.
ARCHIVES OF PHARMACAL RESEARCH.
46,
7
(2023)
Varicella-Zoster Virus ORF39 Transmembrane Protein Suppresses Interferon-Beta Promoter Activation by Interacting with STING.
JOURNAL OF MICROBIOLOGY.
61,
2
(2023)
G-quadruplexes formed by Varicella-Zoster virus reiteration sequences suppress expression of glycoprotein C and regulate viral cell-to-cell spread.
PLOS PATHOGENS.
19,
1
(2022)
YAP inhibits HCMV replication by impairing STING-mediated nuclear transport of the viral genome.
PLOS PATHOGENS.
18,
12
(2022)
Virus blocking textile for SARS-CoV-2 using human body triboelectric energy harvesting.
CELL REPORTS PHYSICAL SCIENCE.
3,
4
(2022)
Analysis of Novel Drug-Resistant Human Cytomegalovirus DNA Polymerase Mutations Reveals the Role of a DNA-Binding Loop in Phosphonoformic Acid Resistance.
FRONTIERS IN MICROBIOLOGY.
13,
1
(2021)
Human Cytomegalovirus UL48 Deubiquitinase Primarily Targets Innermost Tegument Proteins pp150 and Itself To Regulate Their Stability and Protects Virions from Inclusion of Ubiquitin Conjugates.
JOURNAL OF VIROLOGY.
95,
23
(2021)
Localization of the WD Repeat-Containing Protein 5 to the Virion Assembly Compartment Facilitates Human Cytomegalovirus Assembly.
JOURNAL OF VIROLOGY.
95,
8
(2020)
Gamma secretase inhibition impairs HCMV replication by reduction of immediate early gene expression at the transcriptional level.
ANTIVIRAL RESEARCH.
183,
(2020)
Degradation of SAMHD1 Restriction Factor Through Cullin-Ring E3 Ligase Complexes During Human Cytomegalovirus Infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.
10,
1
(2020)
The Human Cytomegalovirus Transmembrane Protein pUL50 Induces Loss of VCP/p97 and Is Regulated by a Small Isoform of pUL50.
JOURNAL OF VIROLOGY.
94,
13
(2019)
Unraveling the Regulatory G-Quadruplex Puzzle: Lessons From Genome and Transcriptome-Wide Studies.
FRONTIERS IN GENETICS.
10,
1
(2019)
Whole Transcriptome Analyses Reveal Differential mRNA and microRNA Expression Profiles in Primary Human Dermal Fibroblasts Infected with Clinical or Vaccine Strains of Varicella Zoster Virus.
PATHOGENS.
8,
4
(2019)
Sumoylation of a small isoform of NFATc1 is promoted by PIAS proteins and inhibits transactivation activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
513,
1
(2018)
Expression of Human Cytomegalovirus IE1 Leads to Accumulation of Mono-SUMOylated PML That Is Protected from Degradation by Herpes Simplex Virus 1 ICP0.
JOURNAL OF VIROLOGY.
92,
23
(2018)
Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus.
PLOS PATHOGENS.
14,
9
(2018)
Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L.
JOURNAL OF VIROLOGY.
92,
15
(2018)
Analysis of IE62 mutations found in Varicella-Zoster virus vaccine strains for transactivation activity.
JOURNAL OF MICROBIOLOGY.
56,
6
(2017)
Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP- Mediated IFN-beta Induction.
FRONTIERS IN MICROBIOLOGY.
8,
단행본
(2021)
의학미생물학 (8판).
범문에듀케이션.
공동
(2020)
미생물학-기초에서 응용까지, Chapter 11 바이러스의 분자생물학.
범문에듀케이션.
공동
(2020)
우리가 몰랐던 바이러스 이야기-바이러스 태아감염: 소두증 위협.
범문에듀케이션.
주저자
(2018)
간호미생물학 4판.
현문사.
공동
(2017)
미생물학, Chapter 13. 바이러스의 분자생물학.
법문사.
공동
(2014)
의학미생물학 7판.
엘스비어코리아 (유).
공동
(2013)
바이러스학 제3판.
(주)라이프사이언스.
공동
(2010)
바이러스학 제2판, 대표저자 류왕식, 라이프사이언스.
라이프사이언스.
공동
(2004)
바이러스학.
정문각.
단독
특허/프로그램
RNF170 및 pUL50을 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물(A pharmaceutical composition for preventing or treating cancer comprising RNF170 and pUL50 as an active ingredient).
10-2018-3410000.
20190829.
대한민국
SUMO-Ubc9 fusion protein that enahnces SUMOylation of proteins containing a SUMO-interacting motif (SIM).
10-2009-0079371.
20120904.
대한민국
인간 사이토메갈로바이러스 복제 억제제를 선별하기 위한 UL112-113 스크리닝 단백질 및 이를 이용한 스트리닝 방법.
10-0792223.
20071231.
대한민국
수상/공훈
한탄상, 한탄생명과학재단 (2015)
우수연구자상, 성균관대학교 의과대학 (2017)
대한바이러스학회 회장 (2018-2019)
학술회의논문
(2021)
G-quadruplex formation in the lytic replication origin of human cytomegalovirus is essential for viral DNA replication.
2021 International Conference of The Korean Society for Molecular And Cellular Biology.
대한민국
(2021)
G-quadruplex-mediated suppression of ORF14 transcription in Varicella-Zoster virus.
The 45th International Herpesvirus Workshop 2021.
미국
(2021)
Identification of cellular proteins regulated by Cullin-Ring E3 ubiquiti ligases during human cytomegalovirus infection.
The 28th Federation Meeting of Korean Basic Medical Scientists.
대한민국
(2021)
Regulation of the type-I interferon-ISGylation axis by human cytomegalovirus UL26 protein.
The 28th Federation Meeting of Korean Basic Medical Scientists.
대한민국
(2020)
Degradation of SAMHD1 restriction factor through Cullin-Ring E3 ligase complexes during human cytomegalovirus infection.
International Union of Microbiological Societies (IUMS) 2020.
대한민국
(2020)
HCMV regulation of ubiquitin pathways.
International Union of Microbiological Societies (IUMS) 2020.
대한민국
(2020)
Human cytomegalovirus deubiquitinase activity is necessary for efficient accumulation of viral proteins during productive infection.
International Union of Microbiological Societies (IUMS) 2020.
대한민국
(2020)
Regulation of VCP/p97 expression by HCMV UL50-encoded transmembrane proteins.
2020 Protein Metabolism & Diseases Symposium, Korean Society for Molecular and Cellular Biology.
대한민국
(2020)
Regulation of CMV infection by G-quadruplex.
2020 International conference: Korean Society for Molecular and Cellular Biology.
대한민국
(2020)
The human cytomegalovirus transmembrane protein pUL50 induces loss of VCP/p97 and is regulated by a small isoform of pUL50.
2020 Korean Society of Virology E-Conference..
대한민국
(2019)
Downregulation of SAMHD1 expression by the CUL2-associated CRL complex during human cytomegalovirus infection.
2019 Annual Meeting of the Federation of Korean Microbiological Societies.
대한민국
(2019)
Genome-wide analysis of the putative G-quadruplex-forming sequences in Varicella-Zoster virus.
2019 Annual Meeting of the Federation of Korean Microbiological Societies.
대한민국
(2019)
Uncovering new cytomegalovirus functions that regulate innate immune responses.
2019 International conference: Korean Society for Molecular and Cellular Biology.
대한민국
(2019)
Interplay of HCMV and ISGylation.
The 17th Protein Metabolism & Diseases (PMD) Conference.
대한민국
(2019)
Genetic and structural characterization of novel drug resistant cytomegalovirus DNA polymerase mutations found in a pediatric hematopoietic cell transplant recipient.
2019 Korean Society of Virology Conference.
대한민국
(2019)
Regulation of VCP/p97 expression by HCMV-encoded UL50 transmembrane proteins.
2019 Korean Society of Virology Conference.
대한민국
(2019)
A small UL50 isoform promotes viral gene expression by counteracting pUL50-mediated VCP/p97 destabilization in HCMV infection.
The 44th International Herpesvirus Workshop 2019.
미국
(2018)
Effect of the vaccine–type mutation found in ORF39 encoding an integral membrane protein on VZV growth. 2018 Korean Society of Virology Conference. Korea University, Seoul, Korea (녹십자 100%).
2018 대한바이러스학회 연구회연합 정기학술대회.
대한민국
(2018)
Transcriptome analysis of VZV infection in mouse dorsal root ganglia.
2018 International Meeting of the Federation of Korean Microbiological Societies.
대한민국
(2018)
Transmembrane protein pUL50 of human cytomegalovirus inhibits ISGylation by downregulating UBE1L.
2018 International Meeting of the Federation of Korean Microbiological Societies.
대한민국
